|
KMID : 0356920070520060687
|
|
Korean Journal of Anesthesiology
2007 Volume.52 No. 6 p.687 ~ p.693
|
|
|
Effects of Long-term Intermittent Oxygen Administration on the Cognitive Function in Rats
|
|
Koo Seung-Lyong
Kim Chul-Hyun
Ahn Hae-Chul
Kim Dong-Won
Kim Kyoung-Hun
Kim Chan
|
|
|
Abstract
|
|
|
Background: Several studies have demonstrated that the transient administration of oxygen improves cognitive performance. However, the effect of long-term oxygen administration remains unknown. This study investigated the impact of long-term oxygen administration on cognitive enhancement.
Methods: Six week old Sprague-Dawley rats (n = 46) were randomly allocated to one of three groups: the control (Control; n = 15), 30 min/day oxygen administration (Oxy30min; n = 16) and 60 min/day oxygen administration groups (Oxy60min; n = 15). The rats in all three groups were administered air or oxygen for 10 weeks. The Morris water maze test was employed to assess the latency (L & Lt), dwelling time (DT) and the total fraction above the mean dwelling time (FmDT) for cognitive performance.
Results: Compared to the control group, the Oxy30min and Oxy60min groups showed no differences in their L and Lt. There was a dose-response trend due to oxygen administration. Compared to the control group, the Oxy60min group had a significantly improved DT (P ＜ 0.05). The FmDT also significantly increased in both of the oxygen administration groups, which also showed a dose-response trend (P ＜ 0.05).
Conclusions: The present results suggest that long-term (10 weeks) oxygen administration can dose-dependently enhance cognitive performance. (Korean J Anesthesiol 2007; 52: 687∼93)
|
|
|
KEYWORD
|
|
|
cognitive function, long-term oxygen administration, water maze
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|